| 摘要 |
<p>Provided herein are novel sirtuin-modulating compounds of formula: (see formula II) The sirtuin-modulating compoundsmay be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including,for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.</p> |
