SYSTEMS AND METHODS FOR COLLECTING TEAR FILM AND MEASURING TEAR FILM OSMOLARITY

摘要

A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

主权项

1. A method for detecting or measuring a protein of interest in tear fluid, comprising:
i) contacting a substrate with an aliquot volume of tear fluid; ii) transferring optical energy to the aliquot volume of tear fluid; and iii) detecting energy transfer properties of the aliquot volume of tear fluid to produce a tear fluid reading, wherein the tear fluid reading is correlated to presence or quantity of a protein of interest in the aliquot volume of tear fluid.