METHOD FOR ESTABLISHING THE SOURCE OF INFECTION IN A CASE OF FEVER OF UNCLEAR AETIOLOGY

摘要

Use of gene expression profiles obtained in vitro from a patient's sample for establishing the local infection of a “fever of unknown origin”, wherein the gene expression profiles are specific for local inflammations of a “fever of unknown origin”, such as peritonitis, pneumonia, endocarditis or infections of the urea tract.

主权项

1. A method for treatment of a local inflammation of a fever of unknown origin (FOU) in a human, comprising:
i. isolating a blood sample from a patient with a FUO; ii. obtaining gene expression profiles from the blood sample of the patient;
wherein probes are used for obtaining the gene expression profiles;wherein the probes comprise sequences that are specific only to the polynucleotides of SEQ-ID No. 1 to SEQ-ID No. 432 or sequences that are 80% homologous to the polynucleotides thereof; iii. comparing the gene expression profiles of the patient to the gene expression profiles of a control group; iv. utilizing the comparison to diagnose the local inflammation of the FUO; and v. administering appropriate therapeutic measures to treat the FUO.