Solid oral pharmaceutical compositions comprising fixed dose combination of metformin and sitagliptin or salts thereof.

摘要

The present invention provides solid oral pharmaceutical compositions comprising combination of metformin and sitagliptin or salts thereof. In particular, the present invention relates to a multilayered coated pharmaceutical composition comprising at least two compartments of metformin or salts thereof exhibiting immediate and extended release and at least one compartment of sitagliptin and metformin or salts thereof exhibiting immediate release. The invention also includes process of preparing such compositions and method of use of such compositions for treating type II diabetes.

主权项

1. A solid oral pharmaceutical composition comprising:
(a) at least one first component comprising sitagliptin, metformin or salts thereof and one or more pharmaceutical excipients exhibiting immediate release; (b) at least one second component comprising metformin or salt thereof and one or more pharmaceutical excipients exhibiting extended release, and (c) at least one third component comprising metformin or salts thereof and one or more pharmaceutical excipients exhibiting immediate release, wherein the first and second components are at least partially coated with the third component.