METHOD AND SYSTEM FOR CHARACTERIZING TISSUE IN THREE DIMENSIONS USING MULTIMODE OPTICAL MEASUREMENTS

摘要

A method and system are provided for characterizing a portion of biological tissue. A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue. The intensity of the illumination light remitted from the tissue in response to the illumination over a known measurement window is measured over a hyperspectral range of wavelengths for at least two distinguishable polarization components. Based on a model of the response of the tissue and the preceding measurements, data representative of the location and one or more characteristics of an abnormal portion of the tissue are produced. A method is provided to eliminate the masking effect of melanin to obtain accurate estimations of an anomaly.

主权项

1. A method of characterizing biological tissue, comprising:
illuminating tissue in vivo with multiple wavelengths light having at least two distinguishable polarization modes; separating light remitted from said tissue in response to said illumination into at least two distinguishable polarization components; forming at least two respective hyperspectral image sets from said at least two distinguishable polarization components; and based on the spatial, spectral and polarization characteristics of the at least two respective image sets, determining at least one characteristic of said tissue.