UNDIFFERENTIATED CELL ELIMINATION METHOD

摘要

An object of the present invention is to provide a method for introducing a target substance into undifferentiated cells, and a carrier therefor, whereby the target substance can be specifically introduced into the undifferentiated cells by contacting the undifferentiated cells with an rBC2LCN-target substance fusion product in which rBC2LCN lectin is fused to the target substance. Particularly, an rBC2LCN-toxin fusion product in which rBC2LCN lectin is fused to a toxin functioning in cells or its domain having the ability to kill cells functions as an agent for eliminating undifferentiated stem cells and can be administered into a medium after inducing the differentiation of the stem cells to reliably kill only the stem cells in an undifferentiated state.

主权项

1. A method for introducing a target substance into undifferentiated cells, comprising chemically or electrically fusing the target substance to rBC2LCN, and contacting the resultant rBC2LCN-target substance fusion product with the undifferentiated cells.