Stable Glucagon Formulations

摘要

Stabilized formulations containing a peptide, such as a glucagon, are described herein. The formulations are in the form of a solution or suspension, which exhibit ttle or no chemical degradation and/or aggregation of the peptide over an extended period of time. In some embodiments, the formulations are in the form of a solution containing the peptide, a solvent such as glycerin, and one or more thermal stabilizers. In other embodiments, the formulation is in the form of a suspension containing nano- and/or microparticles containing the peptide suspended in a non- aqueous, non-solvent. The nano- and/or microparticles can be prepared by micronizing the peptide with one or more humectants, such as salts, sugars, water-soluble polymers, and combinations thereof which increase the rate of dissolution of the peptide upon administration.

主权项

1. A stabilized peptide formulation comprising a peptide dissolved in glycerin,
wherein the formulation contains less than 5%, 1%, 0.5%, 0.25%, 0.1%, or 0.05%, weight by volume of water, and wherein the peptide is glucagon.