Imaging compounds for tracking histone deacetylase inhibitor and synthesis method thereof

摘要

A synthesis method of labeling histone deacetylase inhibitor (HDAC inhibitors) SC027 with Gallium-67 or Gallium-68 radionuclide, wherein a labeled precursor DOTA-SC027 which comprises DOTA-NHS-ester (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-N-hydroxysuccinimide-ester) and HDACi-SC027 is prepared for the synthesis to label HDACi-SC027 with Gallium-67 or Gallium-68 radionuclide for producing imaging tracers for tracking the HDACi.

主权项

1. An imaging compound used as a tracer of histone deastylase inhibitors for diagnosis of tumors in nuclear medicine, wherein the compound is synthesized by labeling radionuclide and histone deastylase inhibitor SC027 having chemical formula:chemical name: 4-Acetylamino-N-(2′-aminophenyl)benzamide, commercial name: Acetyldinaline or Tacedinaline, and empirical formula: C15H15N3O2.