DEAMORPHIZATION OF SPRAY-DRIED FORMULATIONS VIA SPRAY-BLENDING

摘要

Dry powder formulations for inhalation and their use in the treatment diseases and conditions. The formulation contains a uniform blend of a first spray-dried powder and a second spray-dried powder. The first spray-dried powder contains spray-dried particles of a therapeutically active ingredient dispersed in a pharmaceutically acceptable hydrophobic excipient. The second spray-dried powder contains spray-dried particles formed from a pharmaceutically acceptable hydrophobic excipient but are substantially free of any therapeutically active ingredient. The active ingredient in the first spray-dried powder is loaded sufficiently high to compensate for the second spray-dried powder being substantially free of any active ingredient. A process for preparing such formulations is also described.

主权项

1. A powder formulation for inhalation, comprising a substantially uniform blend of a first engineered powder and a second engineered powder,
said first engineered powder comprising first spray-dried particles comprising a crystalline therapeutically active ingredient dispersed in a pharmaceutically acceptable hydrophobic excipient; said second engineered powder comprising second spray-dried particles of a pharmaceutically acceptable hydrophobic excipient, wherein the second spray-dried particles are substantially free of any therapeutically active ingredient; and wherein a loading of the active ingredient in said first engineered powder is sufficiently high to achieve a desired target dose of the active ingredient.