COMPOSITIONS SUPPORTIVE FOR TREATING DRUG-RESISTANCED BREAST CANCER CONTAINING MIR-500A-3P AND SENSITIZING METHOD FOR ANTICANCER REAGENT IN DRUG-RESISTANCED BREAST CANCER PATIENT

摘要

The present invention relates to a method for recovering sensitivity to an anticancer agent of a breast cancer patient with anticancer agent tolerance by expressing or adding miR-500a-3p and to a treatment supplement agent including miR-500a-3p. According to the present invention, a mechanism that tolerance for an anti-hormone treatment agent such as tamoxifen as a breast cancer treatment agent is generated; activation of miR-500a-3p in a breast cancer cell with LY6K overexpression recovers sensitivity to tamoxifen by re-expression of ERα; and a method for preventing anticancer agent tolerance and recovering sensitivity to an anticancer agent. In addition, according to the present invention, a reverse correlation between LY6K and ERα. Sensitivity to tamoxifen can be increased as upward regulation of miR-500a-3p, which is induced by ERα, inhibits expression of LY6K in an ERα-negative breast cancer cell.