Modified Streptococcus Pneumoniae Pneumolysin (PLY) Polypeptides

摘要

This disclosure relates to immunogenic compositions comprising mutant Streptococcus pneumonia pneumolysin (PLY) proteins. Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.

主权项

1. An isolated polypeptide consisting of a wild-type pneumolysin polypeptide comprising at least one amino acid substitution at an amino acid selected from the group consisting of threonine 65, glycine 293, and cysteine 428.