COMPOUNDS THAT BIND DYSTROGLYCAN AND USES THEREOF

摘要

Disclosed herein are methods and compositions involved in identifying cells that lack apico-basal polarity as well as methods and compositions involved in selectively delivering payload molecules to cells that lack apico-basal polarity, and methods of selecting test compounds that restore apico-basal polarity.

主权项

1. A method of identifying a cell as lacking apico-basal polarity, the method comprising:
contacting the cell with a reagent that specifically binds dystroglycan or a homolog thereof, the reagent further comprising a label; observing assembly of the label on the cell surface or internalization of the label into acidic vesicles; wherein assembly of the label or internalization of the label into the cell is an indication that the cell lacks apico-basal polarity.