| 发明名称 |
CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE |
| 摘要 |
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection. |
| 申请公布号 |
US2015374812(A1) |
申请公布日期 |
2015.12.31 |
| 申请号 |
US201414765365 |
申请日期 |
2014.02.05 |
| 申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ;THE GOVERNMENT OF USA, REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICE ;THERMO FISHER SCIENTIFIC BIOSCIENCES INC. |
发明人 |
Karpilow Jon Michael;Oberste Mark Steven;Tripp Ralph A.;Tompkins Stephen M. |
| 分类号 |
A61K39/13;C12N7/00;C12N15/113 |
主分类号 |
A61K39/13 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. (canceled) |
| 地址 |
Athens GA US |
