CABAZITAXEL AND ITS USE FOR TREATING METASTATIC PROSTATE CANCERS

摘要

The present disclosure relates to the compound having the following formula (I):;which may be in base form or in the form of a hydrate or a solvate,in combination with prednisone or prednisolone,for its use for the treatment of castration resistant or hormone-refractory metastatic prostate cancer in patients not at risk of developing gastrointestinal disorders chosen from the group consisting of: gastrointestinal bleeding and perforation, gastritis, enterocolitis, neutropenic enterocolitis, colitis, intestinal obstruction, and ileus.

主权项

1. A method for treating castration resistant or hormone-refractory metastatic prostate cancer, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I): which may be in base form or in the form of a hydrate or a solvate, in combination with prednisone or prednisolone, wherein the patient is not at risk of developing a gastrointestinal disorder chosen from the group consisting of: gastrointestinal bleeding and perforation, gastritis, enterocolitis, neutropenic enterocolitis, colitis, intestinal obstruction, and ileus.