PULMONARY DELIVERY OF A FLUOROQUINOLONE

摘要

A composition for pulmonary administration comprises a fluoroquinolone betaine, such as ciprofloxacin betaine, and an excipient. In one version, the particles have a mass median aerodynamic diameter from about 1 μm to about 5 μm, and the fluoroquinolone has a half life in the lungs of at least 1.5 hours. The composition is useful in treating an endobronchial infection, such as Pseudomonas aeruginosa, and is particularly useful in treating cystic fibrosis.

主权项

1. A powder composition for pulmonary administration in a unit dose receptacle, the powder composition comprising:
particles comprising a fluoroquinolone in zwitterionic form and an excipient, wherein the fluoroquinolone comprises one or more of cinofloxacin, enoxacin, norfloxacin, ofloxacin, levofloxacin and moxifloxacin, wherein the particles have a mass median aerodynamic diameter from about 1 μm to about 5 μm and wherein the particles have a rugosity of from about 3 to 10.