| 发明名称 |
Crush resistant delayed-release dosage forms |
| 摘要 |
The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed. |
| 申请公布号 |
US2015374630(A1) |
申请公布日期 |
2015.12.31 |
| 申请号 |
US201514848457 |
申请日期 |
2015.09.09 |
| 申请人 |
GRUENENTHAL GMBH |
发明人 |
ARKENAU MARIC Elisabeth;BARTHOLOMÄUS Johannes;KUGELMANN Heinrich;ASHWORTH Judy |
| 分类号 |
A61K9/20;A61K31/55;A61K31/135;A61K31/4418;A61K31/277;A61K31/554;A61K31/485 |
主分类号 |
A61K9/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed. |
| 地址 |
Aachen DE |
