| 发明名称 |
METHOD FOR FORMATION OF MICRO-PRILLED POLYMERS |
| 摘要 |
A method for formation of micro-prilled poloxamer particles is disclosed. The particles find special use in pharmaceutical formulations. The process involves use of atomizing nozzles at higher than normal pressure atomizing gas, high atomizing gas temperature, use of high feed temperatures to reduce the viscosity of the poloxamer and optionally sieving after prill formation in prilling towers. The poloxamer particles are spherical and preferably have an average nominal diameter of less than or equal to 106 microns. The process is very cost effective and rapid. |
| 申请公布号 |
US2015374629(A1) |
申请公布日期 |
2015.12.31 |
| 申请号 |
US201514845760 |
申请日期 |
2015.09.04 |
| 申请人 |
BASF Corporation |
发明人 |
Lisa Rudolph Ernest;Quadir Anisul;Scheper Rebecca Ham;Grzesiowski Peter |
| 分类号 |
A61K9/20;B01J2/04;A61K9/50;A61K31/55;A61K47/34 |
主分类号 |
A61K9/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A plurality of micro-prilled poloxamer particles comprising:
one or more copolymers of ethylene oxide and propylene oxide each having a general formula of HO(C2H4O)a(C3H6O)b(C2H4O)aH, wherein a value of a is from about 60 to about 150 and a value of b is from about 25 to about 60; said particles being spherical, solid at 25° C., and said plurality of particles having an average nominal diameter of less than or equal to 106 microns. |
| 地址 |
Florham Park NJ US |
