发明名称 |
COVALENTLY BONDED DIABODIES HAVING IMMUNOREACTIVITY WITH PD-1 AND LAG-3, AND METHODS OF USE THEREOF |
摘要 |
The present invention is directed to bi-specific diabodies that comprise two or more polypeptide chains and which possess at least one Epitope-Binding Site that is immunospecific for an epitope of PD-1 and at least one Epitope-Binding Site that is immunospecific for an epitope of LAG-3 (i.e., a "PD-I x LAG-3 bi-specific diabody"). More preferably, the present invention is directed to bi-specific diabodies that comprise four polypeptide chains and which possess two Epitope-Binding Sites that are immunospecific for one (or two) epitope(s) of PD-1 and two Epitope-Binding Site that are immunospecific for one (or two) epitope(s) of LAG-3 (i.e., a "PD-1 x LAG-3 bi-specific, tetra-valent diabody"). |
申请公布号 |
WO2015200119(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
WO2015US36634 |
申请日期 |
2015.06.19 |
申请人 |
MACROGENICS, INC. |
发明人 |
BONVINI, EZIO;JOHNSON, LESLIE, S.;SHAH, KALPANA;LA MOTTE-MOHS, ROSS;MOORE, PAUL, A.;KOENIG, SCOTT |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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