| 摘要 |
The invention relates to the probes of formula (I); in which: X1 = NH, O or S; X2 = O or S; SE is a labile group, which may be removed under the action of a stimulus which may in particular be the presence of an enzyme, of a chemical compound or of a physicochemical characteristic of the medium containing the probe; A is an aromatic group, which, after cleavage of the C(X2)-O, linkage in aqueous solution, results in the release of a chomophore or a flurophore; R is a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a link arm, GP is a hydrosolubilizing group, and also the physiologically acceptable salts, solvates or hydrates thereof. The subject matter of the invention is also the intermediates for the synthesis thereof and the detection methods using same. |
