| 发明名称 |
ASYMMETRIC SYNTHESIS OF A SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDE |
| 摘要 |
The present invention provides an improved method for the large scale production of the compound 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid. |
| 申请公布号 |
EP2958893(A1) |
申请公布日期 |
2015.12.30 |
| 申请号 |
EP20140706519 |
申请日期 |
2014.02.18 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
FISHLOCK, DANIEL;GU, CHEN;SHU, LIANHE;REGE, PANKAJ, DEVDATTA;SARMA, KESHAB |
| 分类号 |
C07D207/16 |
主分类号 |
C07D207/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
