| 摘要 |
The invention relates to a transdermal patch with excellent physicochemical characteristics such as: breaking strength, bioadhesion, post-wetting bioadhesion, thickness, chemical content and suitable in vitro dissolution speed, which ensures the suitable release of the active substance in order for same to carry out its therapeutic effect. The patch according to the present invention comprises a polymer matrix with chitosan and a poloxamer, in addition to an active principle and a microneedle, and it is applied directly to the skin of the human patient. The patch satisfies the properties of compatibility in the formulation, and chemical stability, it is non-irritating, it does not render the skin sensitive or cause the build-up of sebaceous material, it is not phototoxic, it is inodorous and colourless, it has good breaking strength and it is bioadhesive. |
