发明名称 |
CELLS FOR PRODUCING RECOMBINANT IDURONATE-2-SULFATASE |
摘要 |
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture. |
申请公布号 |
SG10201509397S(A) |
申请公布日期 |
2015.12.30 |
申请号 |
SG10201509397S |
申请日期 |
2013.06.28 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
BOLDOG, FERENC;HEARTLEIN, MICHAEL |
分类号 |
|
主分类号 |
|
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|