发明名称 |
METHOD FOR PRODUCING α-SUBSTITUTED CYSTEINE OR SALT THEREOF OR INTERMEDIATE FOR SYNTHESIS OF α-SUBSTITUTED CYSTEINE |
摘要 |
According to the present invention, it becomes possible to perform a process for converting into an α-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance. In the production of an α-substituted-D-cysteine or a salt thereof, it becomes possible to perform a process for converting the compound represented by general formula (2) into a compound represented by general formula (3S) in one step by allowing an enzyme or the like to act on the compound represented by general formula (2). |
申请公布号 |
SG11201509022X(A) |
申请公布日期 |
2015.12.30 |
申请号 |
SGX11201509022 |
申请日期 |
2014.05.01 |
申请人 |
API CORPORATION |
发明人 |
ASUMA, YUUKI;UEHARA, HISATOSHI;MAEDA, TOMOKO;SAITO, YASUYO;MIYAKE, RYOMA;KAWABATA, HIROSHI |
分类号 |
C12P13/12;C07C319/02;C07C319/06;C07C319/12;C07C323/52;C07C323/58;C07D277/14;C12N15/09 |
主分类号 |
C12P13/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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