The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analogue thereof at the C-terminus of the fusion protein and a functional variant of human serum albumin at the N-terminus of the fusion protein connected via a peptide linker. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.
申请公布号
CA2952293(A1)
申请公布日期
2015.12.30
申请号
CA20152952293
申请日期
2015.06.17
申请人
NOVO NORDISK A/S
发明人
SHAW, ALLAN CHRISTIAN;HELGSTRAND, CHARLOTTE;SANDRINI, MICHAEL PAOLO BASTNER;JORGENSEN, SEBASTIAN BECK;THOGERSEN, HENNING;SASS-ORUM, KRISTIAN;HASTRUP, SVEN;ANDERSEN, KIM VILBOUR