发明名称 |
TRANSGENIC MOUSE EXPRESSING KIDNEY-SPECIFIC HUMAN TGF-Β1, AND BIO-MARKER FOR TISSUE FIBROSIS MOUSE MODEL |
摘要 |
[Problem] To provide a TG mouse that expresses TGF-β1 specific to the kidneys and spontaneously develops renal fibrosis. This is achieved in the form of a transgenic mouse characterized by including a mouse Podocin promoter area, and an entire gene area of the human transformation factor β1 (human TGF-β1) which is located downstream of the promoter area and of which expression is controlled. At this time, the transgenic mouse preferably develops renal fibrosis or renal insufficiency naturally from 15 weeks after birth, and begins to die at 20 to 26 weeks after birth. |
申请公布号 |
WO2015199144(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
WO2015JP68238 |
申请日期 |
2015.06.24 |
申请人 |
MIE UNIVERSITY |
发明人 |
YANO, YUTAKA;ESTEBAN C. GABAZZA |
分类号 |
A01K67/027;C12N15/09;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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