METHODS FOR TRIGGERING DE NOVO FORMATION OF HETEROCHROMATIN AND OR EPIGENETIC SILENCING WITH SMALL RNAS
摘要
<p>The present application relates to a method for the targeted formation of heterochromatin and/or induction of epigenetic gene silencing in a cell using a small RNA, said method comprising the step of inhibiting the Paf1 complex in said cell and the step of contacting said cell with a small RNA targeted to a region of the genome of the cell, said region being the region where heterochromatin formation and/or induction of epigenetic gene silencing should be induced.</p>
申请公布号
WO2015198202(A1)
申请公布日期
2015.12.30
申请号
WO2015IB54665
申请日期
2015.06.22
申请人
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH;BUEHLER, MARC;KOWALIK, KATARZYNA;SHIMADA, YUKIKO