METHODS AND COMPOSITIONS FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) THERAPY

摘要

Embodiments concern methods and composition related to systemic lupus erythematosus (SLE) therapy, comprising administering certain pharmacentical compositions including a mitochondrial phosphodiesterase (PDE) inhibitor; a mitochondrial protein kinase A (PKA) enhancer; and/or a receptor for advanced glycation end products (RAGE) inhibitor. In certain embodiments, a method for treating a patien is provided. The method comprises administering to the patient a composition comprising an effective amount of: a) a mitochondrial phosphodiesterase (PDE) inhibitor; b) a mitochondrial protein kinase A (PKA) enhancer; and/or c) a receptor for advanced glycation end products (RAGE) inhibitor.