| 发明名称 |
THERMALLY STABLE CRYSTALLINE EPIRUBICIN HYDROCHLORIDE AND METHOD OF MAKING THE SAME |
| 摘要 |
<p>A crystalline form of epirubicin hydrochloride, named herein as "type II" crystalline epirubicin hydrochloride, has excellent thermal stability. Type II crystalline epirubicin hydrochloride has a powder X-ray diffraction pattern having average values of diffraction angle (2theta) and relative intensity P(%) as presented in the following table: <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0"> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="offset" colwidth="35pt" align="left"/> <colspec colname="1" colwidth="42pt" align="center"/> <colspec colname="2" colwidth="140pt" align="center"/> <thead> <row> <entry/> <entry namest="offset" nameend="2" align="center" rowsep="1"/> </row> <row> <entry/> <entry>Diffraction</entry> <entry/> </row> <row> <entry/> <entry>Angle</entry> <entry>Relative Intensity</entry> </row> <row> <entry/> <entry>2Theta</entry> <entry>P (%)</entry> </row> <row> <entry/> <entry namest="offset" nameend="2" align="center" rowsep="1"/> </row> </thead> <tbody valign="top"> <row> <entry/> </row> </tbody> </tgroup> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="offset" colwidth="35pt" align="left"/> <colspec colname="1" colwidth="42pt" align="char" char="."/> <colspec colname="2" colwidth="140pt" align="char" char="."/> <tbody valign="top"> <row> <entry/> <entry>5.236</entry> <entry>9.8</entry> </row> <row> <entry/> <entry>9.212</entry> <entry>12.5</entry> </row> <row> <entry/> <entry>13.732</entry> <entry>15.5</entry> </row> <row> <entry/> <entry>16.446</entry> <entry>4.8</entry> </row> <row> <entry/> <entry>18.234</entry> <entry>5</entry> </row> <row> <entry/> <entry>21.114</entry> <entry>9.7</entry> </row> <row> <entry/> <entry>22.529</entry> <entry>25.5</entry> </row> <row> <entry/> <entry>24.071</entry> <entry>29.9</entry> </row> <row> <entry/> <entry>25.879</entry> <entry>18.4</entry> </row> <row> <entry/> <entry>27.762</entry> <entry>16.5</entry> </row> <row> <entry/> <entry>29.757</entry> <entry>10.1</entry> </row> <row> <entry/> <entry>34.392</entry> <entry>4.4</entry> </row> <row> <entry/> <entry>38.157</entry> <entry>13.1</entry> </row> <row> <entry/> <entry>44.293</entry> <entry>5.9</entry> </row> <row> <entry/> <entry>64.699</entry> <entry>7.7</entry> </row> <row> <entry/> <entry>77.815</entry> <entry>100.</entry> </row> <row> <entry/> <entry namest="offset" nameend="2" align="center" rowsep="1"/> </row> </tbody> </tgroup> </table> </tables></p> |
| 申请公布号 |
EP1638509(B1) |
申请公布日期 |
2015.12.30 |
| 申请号 |
EP20040777189 |
申请日期 |
2004.06.25 |
| 申请人 |
SOLUX CORPORATION |
发明人 |
ZABUDKIN, ALEXANDER;MATVIENKO, VICTOR;MATVYEYEV, ALEXEY;ITKIN, ALEKSANDR |
| 分类号 |
C07H15/24;A61K;A61K31/704;A61P35/00 |
主分类号 |
C07H15/24 |
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