发明名称 |
COMPOSITIONS AND METHODS FOR PROMOTING GROWTH OF BENEFICIAL MICROBES TO TREAT OR PREVENT DISEASE OR PROLONG LIFE |
摘要 |
Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner. |
申请公布号 |
EP2958575(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
EP20140753847 |
申请日期 |
2014.02.19 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
YAMAMOTO, MITSUKO, L.;SCHIESTL, ROBERT, H.;RELIENE, RAMUNE;BORNEMAN, JAMES;PRESLEY, LAURA, L.;BRAUN, JONATHAN |
分类号 |
A61K35/74;A61K35/66;A61P35/00 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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