NICOTINE DOSAGE REGIMEN

摘要

An orally inhalable formulation comprising nicotine or a pharmaceutically acceptable salt thereof and a propellant for use in a method of relieving or preventing nicotine craving associated with tobacco dependence in a subject, wherein a daily dose of inhalable formulation is provided in one or more pressurized containers, wherein the inhalable formulation is for pulmonary administration using a simulated cigarette, said simulated cigarette having a housing, a reservoir configured to receive and contain a charge of inhalable formulation from the pressurized container, and an outlet valve, and wherein said daily dose of inhalable formulation comprises a deliverable daily dose of less than 60 mg of nicotine or a pharmaceutically acceptable salt thereof.