发明名称 |
SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE |
摘要 |
The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules. |
申请公布号 |
EP2958998(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
EP20140754069 |
申请日期 |
2014.02.20 |
申请人 |
SIRNA THERAPEUTICS, INC. |
发明人 |
CHANG, WONSUK;GUIDRY, ERIN, N.;STANTON, MATTHEW, G.;ZEWGE, DANIEL |
分类号 |
C12N15/11;C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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