发明名称 |
Methods for treating, diagnosing and prognosing a haematological malignancy |
摘要 |
The invention relates to a serotonin receptor (5-HTR) inhibitor selected from the group consisting of a type 1 5-HTR inhibitor and a type 2 5-HTR inhibitor for use in the prevention and/or treatment of a haematological malignancy. Additionallly, the invention relates to in vitro methods for the identification or isolation of a malignant cell from a haematological malignancy or for diagnosing a haematological malignancy based on detecting the expression of type 1 5-HTR and/or type 2 5-HTR. Furthermore, the invention relates to in vitro methods for determining the prognosis, for monitoring the effect of a therapy or for designing a customized therapy in a subject suffering from a haematological malignancy based on determining the levels of type 1 5-HTR and/or type 2 5-HTR. |
申请公布号 |
EP2959904(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
EP20140382249 |
申请日期 |
2014.06.27 |
申请人 |
INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS |
发明人 |
MUÑOZ RISUEÑO, RUTH |
分类号 |
A61K31/473;A61K31/495;A61K31/55;A61P35/02;G01N33/00 |
主分类号 |
A61K31/473 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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