发明名称 |
GNRH ANALOG-CYTOTOXIC MOLECULE CONJUGATE AND PREPARATION METHOD AND USE THEREOF |
摘要 |
Provided are a GnRH analog-cytotoxic molecule conjugate as shown by the following formula (I), and a preparation method and a use thereof in the preparation of drugs for treating tumours. The cytotoxic molecule is a taxol derivative or a docetaxel derivative. The conjugate can maintain the binding activity with GnRH receptors, and has a relatively good plasma stability and the growth inhibition activity on tumour cells. (X)Aaa1Aaa2-Aaa3-Ser-Aaa5-Aaa6(Y)-Leu-Aaa8-Pro-Aaa10-NH2 |
申请公布号 |
WO2015196944(A1) |
申请公布日期 |
2015.12.30 |
申请号 |
WO2015CN81781 |
申请日期 |
2015.06.18 |
申请人 |
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA |
发明人 |
LIU, KELIANG;ZHOU, NING;MA, YONGTAO;WANG, CHENHONG;FENG, SILIANG |
分类号 |
C07K7/23;A61K47/48;A61P35/00;C07K1/04;C07K1/06;C07K1/107 |
主分类号 |
C07K7/23 |
代理机构 |
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代理人 |
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地址 |
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