发明名称 |
TEVI CHIMERIC ENDONUCLEASE AND THEIR PREFERENTIAL CLEAVAGE SITES |
摘要 |
<p>The present invention relates to a method to cleave target nucleic acid sequence by the catalytic domain of a GIY-YIG homing endonucleases l-TevI. More precisely, the invention relates to the deciphering of new preferential l-TevI cleavage sites for efficient and specific cleavage activity. The invention concerns a method for the generation of TevI specific chimeric endonucleases to target nucleic acid sequence including such cleavage sites and methods of using same for gene editing.</p> |
申请公布号 |
WO2014118719(A8) |
申请公布日期 |
2015.12.30 |
申请号 |
WO2014IB58646 |
申请日期 |
2014.01.29 |
申请人 |
CELLECTIS |
发明人 |
SILVA, GEORGE;BEURDELEY, MARINE |
分类号 |
C12N9/22;C12N15/82;C12N15/90 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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