Process for preparation of dronedarone by the use of dibutylaminopropanol reagent

摘要

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II)—where L is leaving group—is reacted with compound of formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.;

主权项

1. A process for the preparation of dronedarone (I), or a pharmaceutically acceptable salt thereof, comprising the steps of: a) reacting a compound of formula (II) where L is a leaving group, with a compound of formula (III)or an alkali salt thereof;
b) isolating dronedarone (I); and c) optionally converting dronedarone (I) into a pharmaceutically acceptable salt thereof.