| 摘要 |
This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter. |
| 主权项 |
1. A composition comprising
a surfactant selected from a polyethoxylated hydroxy fatty acid; a microorganism selected from live, killed, attenuated and inactivated microorganisms, wherein the microorganism is a bacterium selected from the group consisting of enterotoxigenic E. coli, Helicobacter pylori, Clostridium difficile, Shigella sonnei, Shigella boydii, Shigella dysenteriae and Shigella flexneri; a glycolipid adjuvant, and a matrix comprising a hydrogel-forming polymer in which the surfactant, the microorganism and the adjuvant are included, wherein the hydrogel-forming polymer is selected from the group consisting of gelatin, agar, agarose, pectin, carrageenan, and chitosan, and combinations thereof;and wherein the composition when combined with water is capable of releasing self-assembly structures comprising surfactant and adjuvant. |
