Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives

摘要

Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

主权项

1. A compound of Formula (II)(a)(i): wherein:
R2 is selected from the group consisting of: H, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, sulfone, sulfoxide, oxo, oxy, nitro, carbonyl, carboxy, amino acid sidechain, amino acid and peptide; wherein said R2 may be optionally substituted from 1 to 4 times with independently selected halo, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amide, thiol, sulfone, sulfoxide, oxo, oxy, carbonyl, or carboxy; andR7 and R8 are each independently selected from the group consisting of: H, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, thiol, sulfone, sulfoxide, oxo, oxy, nitro, carbonyl, carboxy, amino acid sidechain, amino acid and peptide, or wherein R7 and R8 together form a ring; wherein each of said R7 and R8 may be optionally substituted from 1 to 4 times with independently selected halo, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, thiol, sulfone, sulfoxide, oxo, oxy, carbonyl, or carboxy;wherein when R7 or R8 is acyl substituted with phenyl, said phenyl is not substituted with a second phenyl;or a pharmaceutically acceptable salt thereof.