| 发明名称 | Microrna (miRNA) and downstream targets for diagnostic and therapeutic purposes | ||
| 摘要 | In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis. | ||
| 申请公布号 | US9220722(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201314061350 | 申请日期 | 2013.10.23 |
| 申请人 | JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG | 发明人 | Thum Thomas;Bauersachs Johann;Engelhardt Stefan;Gross Carina |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;A61K31/7088;C12N15/113;A61K45/06 | 主分类号 | A61K48/00 |
| 代理机构 | McNeill Baur PLLC | 代理人 | McNeill Baur PLLC |
| 主权项 | 1. A method for treating or preventing fibrosis, comprising administering to a subject having fibrosis or suspected of having fibrosis a modified oligonucleotide consisting of 15 to 24 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is at least 90% complementary to the nucleobase sequence of miR-21 (SEQ ID NO: 1). | ||
| 地址 | Wurzburg DE | ||