Hollow silica nanospheres and methods of making same

摘要

The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene transfer.

主权项

1. A method for preparing a colloidal dispersion of nanospheres comprising:
(a) depositing a silica-shell precursor on a polyamino acid or carboxylate functionalized template particle at a pH range from 5.5 to 9.5 to afford core-shell nanospheres; (b) subjecting said core-shell nanospheres to calcination or washing with an organic solvent to remove the template particle and to form hollow silica nanospheres; and (c) sonicating a solution comprising said hollow silica nanospheres to prepare a colloidal dispersion, wherein the colloidal dispersion of nanospheres is suitable for in vivo administration by injection.