Anti-GPR49 monoclonal antibodies

摘要

Described herein are to antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies.

主权项

1. A monoclonal antibody that binds to G-Protein Coupled Receptor 49 (GPR49) polypeptide, wherein the monoclonal antibody comprises activity capable of causing internalization of GPR49 in cells contacted with the antibody, wherein the monoclonal antibody comprises anticancer activity against human cells in vivo.