| 主权项 |
1. A compound, or a stereoisomer of said compound, or a pharmaceutically acceptable salt of said compound or said stereoisomer, said compound having the structural Formula (I): or a tautomer thereof having the structural Formula (I′): or pharmaceutically acceptable salt thereof, wherein: ring C is selected from the group consisting of: ring A is selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; each ring B (when present) is independently selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; -L1- (when present) independently represents a bond or a divalent moiety selected from the group consisting of -alkyl-, -haloalkyl-, -heteroalkyl-, -alkenyl-, -alkynyl-, —N(R6)—, —NHC(O)—, —C(O)NH—, NHS(O)2—, —S(O)2NH—, —O—CH2—, —CH2—O—, —NHCH2—, —CH2NH—, and —CH(CF3)NH—, —NHCH(CF3)—; m, n, and p are each independently selected integers, wherein: m is 0 or more; n is 0 or 1; and p is 0 or more, wherein the maximum value of m is the maximum number of available substitutable hydrogen atoms on ring A, and wherein the maximum value of p is the maximum number of available substitutable hydrogen atoms on ring B; each R1 (when present) is independently selected from the group consisting of: H, halogen, —OH, —CN, —SF5, —OSF5, —Si(R5)3, —N(R6)2, —NR7C(O)R6, —NR7S(O)2R6, —NR7C(O)N(R6)2, —NR7C(O)OR6, —OR6, —SR6, —C(O)R6, —C(O)2R6, —C(O)N(R6)2, —P(O)(OR5)2, —P(O)(OR5)(R5), —S(O)R6, —S(O)2R6, —S(O)2N(R6)2, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, aryl, -alkyl-aryl, monocyclic heteroaryl, -alkyl-(monocyclic heteroaryl), monocyclic cycloalkyl, -alkyl-(monocyclic cycloalkyl), monocyclic heterocycloalkyl, a multicyclic group, and -alkyl-(multicyclic group); wherein said alkyl, said haloalkyl, said heteroalkyl, said alkenyl, said alkynyl, said aryl, said -alkyl-aryl, said monocyclic heteroaryl, said -alkyl-(monocyclic heteroaryl), said monocyclic cycloalkyl, said -alkyl-(monocyclic cycloalkyl), said monocyclic heterocycloalkyl, said multicyclic group, and said -alkyl-(multicyclic group) of R1 is optionally unsubstituted or substituted with one or more groups independently selected from R8; each R1H is independently selected from the group consisting of: H, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, aryl, -alkyl-aryl, monocyclic heteroaryl, -alkyl-(monocyclic heteroaryl), monocyclic cycloalkyl, -alkyl-(monocyclic cycloalkyl), monocyclic heterocycloalkyl, a multicyclic group, -alkyl-(multicyclic group), —C(O)R6, —C(O)2R6, —C(O)N(R6)2, —P(O)(OR5)2, —P(O)(OR5)(R5), —S(O)R6, —S(O)2R6, and —S(O)2N(R6)2 wherein said alkyl, said haloalkyl, said heteroalkyl, said alkenyl, said alkynyl, said aryl, said -alkyl-aryl, said monocyclic heteroaryl, said -alkyl-(monocyclic heteroaryl), said monocyclic cycloalkyl, said -alkyl-(monocyclic cycloalkyl), said monocyclic heterocycloalkyl, said multicyclic group, and said -alkyl-(multicyclic group), of R1H is optionally unsubstituted or substituted with one or more groups independently selected from R8; each R2 (when present) is independently selected from the group consisting of: halogen, —OH, —CN, —SF5, —OSF5, —NO2, —Si(R5)3, —P(O)(OR5)2, —P(O)(OR5)(R5), —N(R6)2, —NR7C(O)R6, —NR7S(O)2R6, —NR7C(O)N(R6)2, —NR7C(O)OR6, —C(O)R6, —C(O)2R6, —C(O)N(R6)2, —S(O)R6, —S(O)2R6, —S(O)2N(R6)2, —OR6, —SR6, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, and heterocycloalkyl, wherein said alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, and heterocycloalkyl of R2 are each optionally unsubstituted or substituted with one or more groups independently selected from R8; each R3 (when present) is independently selected from the group consisting of: halogen, —OH, —CN, —SF5, —OSF5, —NO2, —Si(R5)3, —P(O)(OR5)2, —P(O)(OR5)(R5), —N(R6)2, —NR7C(O)R6, —NR7S(O)2R6, —NR7C(O)N(R6)2, —NR7C(O)OR6, —C(O)R6, —C(O)2R6, —C(O)N(R6)2, —S(O)R6, —S(O)2R6, —S(O)2N(R6)2, —OR6, —SR6, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, and heterocycloalkyl, wherein said alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, and heterocycloalkyl of R2 are each optionally unsubstituted or substituted with one or more groups independently selected from R8; R4 is selected from the group consisting of H, halogen, optionally substituted alkyl, optionally substituted -alkyl-OH, optionally substituted heteroalkyl, optionally substituted -alkyl-cycloalkyl, optionally substituted -alkyl-aryl, and optionally substituted -alkyl-heteroaryl, wherein said optional substituents are each independently selected from R8; each R5 (when present) is independently selected from the group consisting of H, alkyl, aryl, arylalkyl-, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, heteroaryl, and heteroarylalkyl-; each R6 (when present) is independently selected from the group consisting of H, alkyl, -alkyl-OH, alkenyl, heteroalkyl, -heteroalkyl-OH, haloalkyl, -haloalkyl-OH, cycloalkyl, lower alkyl-substituted cycloalkyl, lower alkyl-substituted -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein each said aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R6 is unsubstituted or substituted with one or more groups independently selected from halogen, alkyl, heteroalkyl, haloalkyl, alkoxy, heteroalkoxy, and haloalkoxy; each R7 (when present) is independently selected from the group consisting of H, alkyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl; and each R8 (when present) is independently selected from the group consisting of halogen, —OH, —CN, —SF5, —OSF5, alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, —O-alkyl-cycloalkyl, heteroalkyl, —O-heteroalkyl, and -alkyl-OH; wherein each said multicyclic group (when present) is selected from the group consisting of bicyclic aryl, bicyclic heteroaryl, bicyclic cycloalkyl, bicyclic cycloalkenyl, bicyclic heterocycloalkyl, bicyclic heterocycloalkenyl, tricyclic aryl, tricyclic heteroaryl, tricyclic cycloalkyl, tricyclic cycloalkenyl, tricyclic heterocycloalkyl, and tricyclic heterocycloalkenyl. |
