Method of making fatty acid N-acylalkanolamines

摘要

The present invention relates to methods for making a fatty acid N-acylalkanolamine having the formula:;
One of the methods comprises the steps of providing a vinyl ester of a fatty acid having the formula:
;
providing a primary or secondary alkanolamine having the formula: NHR1R2; and reacting the vinyl ester of the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine. The other method comprises the steps of providing a fatty acid; purifying the fatty acid; providing a primary or secondary alkanolamine having the formula: NHR1R2; reacting the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine; and purifying the formed fatty acid N-acylalkanolamine.

主权项

1. A method for making a fatty acid N-acylalkanolamine having the formula: whereinis derived from a natural or synthetic fatty acid;
R1 is a substituted or unsubstituted C1 to C10 hydroxyalkyl; R2 is H, R1 or a C1 to C10 hydrocarbon radical,said method comprising:
providing a fatty acid; purifying the fatty acid; providing a primary or secondary alkanolamine having the formula: NHR1R2; reacting the purified fatty acid with the alkanolamine under the condition effective to form the fatty acid N-acylalkanolamine; and purifying the formed fatty acid N-acylalkanolamine.