Methods using desmopressin acetate in orodispersible form

摘要

Described are orodispersible solid dosage forms of desmopressin or a pharmaceutically acceptable salt thereof useful for treating diseases or conditions such as incontinence, primary nocturnal enuresis (PNE), nocturia, and central diabetes insipidus. The dosage forms disintegrate in the mouth within 10 seconds and provide good desmopressin bioavailability.

主权项

1. A method of treating a disease or condition selected from the group consisting of incontinence, primary nocturnal enuresis (PNE), nocturia, and central diabetes insipidus, comprising administering to a subject in need thereof an effective and generally non-toxic amount of desmopressin acetate in an orodispersible solid dosage form, wherein the dosage form (A) disintegrates in the mouth within 10 seconds and (B) comprises an amount of desmopressin acetate, measured as the free base, of from 0.5 μg to 75 μg, and wherein the method results in a desmopressin bioavailability of from greater than 0.1% to about 0.38%.