| 发明名称 | Mutant polypeptides and uses thereof | ||
| 摘要 | The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided. | ||
| 申请公布号 | US9220742(B1) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201514800961 | 申请日期 | 2015.07.16 |
| 申请人 | INVISTA NORTH AMERICA S.A.R.L. | 发明人 | Botes Adriana;Kadi Nadia;Azoitei Mihai Luchian;Ban Yih-En A;Grabs-Röthlisberger Daniela;Pisarchik Alexander;Zanghellini Alexandre;Althoff Eric |
| 分类号 | A61K38/51;C12N9/90;A61K38/00 | 主分类号 | A61K38/51 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. |
| 主权项 | 1. A polypeptide comprising the amino acid sequence of SEQ ID NO:462, wherein SEQ ID NO:462 is a triple mutant of SEQ ID NO:1 carrying the following three mutations: F382W, L328V, and I187M; or a signal-peptide-less version thereof (SEQ ID NO:460). | ||
| 地址 | Wilmington DE US | ||