Passive methods for anti-microbial biological meshes

摘要

Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.

主权项

1. A modified tissue matrix prepared by a process comprising:
selecting an acellular dermal matrix; and contacting the acellular dermal matrix with a solution consisting essentially of an aqueous buffer and chlorhexidine, wherein the chlorhexidine stably binds to the acellular dermal matrix by passive adsorption, and wherein the aqueous buffer is non-denaturing.