| 发明名称 | Antibody against the CSF-1R | ||
| 摘要 | The present invention provides antibodies specific for the CSF-1R, compositions comprising said antibodies and methods of treatment using such compositions. | ||
| 申请公布号 | US9221912(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201313932285 | 申请日期 | 2013.07.01 |
| 申请人 | Transgene S.A. | 发明人 | Haegel Hélène;Thioudellet Christine;Geist Michel;Grellier Benoît |
| 分类号 | C07H21/04;C07K16/28;A61K39/00 | 主分类号 | C07H21/04 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. |
| 主权项 | 1. An isolated nucleic acid encoding an antibody that specifically binds to human CSF-1R, the antibody comprising a heavy chain variable region comprising (a) a CDR1 comprising the amino acid sequence starting at position 45 and finishing at position 54 of SEQ ID NO:2,(b) a CDR2 comprising the amino acid sequence starting at position 66 and finishing at position 87 of SEQ ID NO:2, and(c) a CDR3 comprising the amino acid sequence starting at position 117 and finishing at position 126 of SEQ ID NO:2; and a light chain variable region comprising (a) a CDR1 comprising the amino acid sequence starting at position 44 and finishing at position 56 of SEQ ID NO:4,(b) a CDR2 comprising the amino acid sequence starting at position 66 and finishing at position 76 of SEQ ID NO:4, and(c) a CDR3 comprising the amino acid sequence starting at position 109 and finishing at position 117 of SEQ ID NO:4. | ||
| 地址 | Illkirch Graffenstaden FR | ||