| 发明名称 | 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals | ||
| 摘要 | Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza. | ||
| 申请公布号 | US9221859(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201414330855 | 申请日期 | 2014.07.14 |
| 申请人 | The University of British Columbia | 发明人 | Withers Stephen;Watts Andrew Graham;Kim Jin Hyo;Wennekes Tom |
| 分类号 | C07D309/02;C07H15/12;C07H13/04;C07H13/12;C07H15/18;C07H1/00;C07H13/00 | 主分类号 | C07D309/02 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Ng Rudy J.;Francis Carol L.;Bozicevic, Field & Francis LLP |
| 主权项 | 1. A method comprising: reacting a compound SAN3: with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) in the presence of MeNO2/H2O for at least 4 days to form compound 1:and reacting compound 1 with diethylaminosulfur trifluoride (DAST) in CH2Cl2 at a temperature of −30° C. to 0° C. to form compound 2: | ||
| 地址 | Vancouver CA | ||