发明名称 Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
摘要 The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
申请公布号 US9221810(B2) 申请公布日期 2015.12.29
申请号 US201514637223 申请日期 2015.03.03
申请人 Nivalis Therapeutics, Inc. 发明人 Sun Xicheng;Qiu Jian;Stout Adam
分类号 C07D215/04;A61K31/44;C07D417/10;C07D215/20;C07D217/16;C07D239/34;C07D241/42;C07D253/10;C07D401/04;C07D401/10;C07D403/10;C07D405/04;C07D409/04;C07D413/10;C07C65/105;C07C65/24;C07D213/79;C07D239/28;C07D241/24;C07D295/155;C07D215/06;C07D239/74;C07D409/14;C07D215/60;C07D239/26;C07D217/04 主分类号 C07D215/04
代理机构 Swanson & Bratschun, L.L.C. 代理人 Swanson & Bratschun, L.L.C.
主权项 1. The compound of Formula I: wherein Z1 is selected from the group consisting of CR2a and N; Z2 is selected from the group consisting of CR2b and N; Z3 is selected from the group consisting of CR2 and N; with the proviso that at least 1 of Z1, Z2, or Z3 must be N; m is selected from the group consisting of 0, 1, 2, or 3; R1 is independently selected from the group consisting of chloro, fluoro, and bromo; R2a, R2b, and R2c, are independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and N(CH3)2; X is selected from the group consisting of n is selected from 0, 1, and 2; R3 is independently selected from the group consisting of halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and NR4R4′ where R4 and R4′ are independently selected from the group consisting of C1-C3 alkyl, or R4 when taken together with R4′ form a ring with 3 to 6 members; A is selected from the group consisting of or a pharmaceutically acceptable salt, stereoisomer, or N-oxide thereof.
地址 Boulder CO US