Angiotensin II alone or in combination for the treatment of hypotension

摘要

The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.

主权项

1. A method of treating a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to above about 5 mcg/min of norepinephrine, comprising:
administering angiotensin II to the subject at a rate effective to raise or maintain mean arterial pressure (MAP) of the subject above about 80 mm Hg; reducing the dose of the catecholamine, while maintaining the MAP of the subject above about 80 mm Hg; and reducing the rate at which angiotensin II is administered, while maintaining the MAP of the subject above about 80 mm Hg.