发明名称 |
N-acetyl amino acid ESTER derivatives of Betulin and preparation method thereof |
摘要 |
The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values. |
申请公布号 |
US2015368291(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
US201514598842 |
申请日期 |
2015.01.16 |
申请人 |
Northeast Forestry University |
发明人 |
WANG Yang;ZHANG Sheng;DING Weiming;YU Tao;YAN Xiufeng |
分类号 |
C07J53/00 |
主分类号 |
C07J53/00 |
代理机构 |
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代理人 |
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主权项 |
1. An N-acetyl amino acid ester derivative of betulin, wherein the derivative has the following structural formula I: wherein R is selected from one of |
地址 |
Heilongjiang CN |